Tolerable daily intake
Z TSENZ
- Slovak term: Slovenský termín
- Estimated maximum amount of an agent, expressed on a body mass basis, to which individuals in a (sub)population may be exposed daily over their lifetimes without appreciable health risk (WHO 2004).
Acronym: TDI
Explanation
The TDI is an estimate of the amount of a substance in food and drinking-water, expressed on a body weight basis (mg/kg or mg/kg of body weight), that can be ingested over a lifetime without appreciable health risk (WHO 2006).
It should be noted that the terms ADI and TDI are used in different context and are not synonymous.
Example
As it relates to administration in drinking-water, for chemicals that give rise to such toxic effects, a tolerable daily intake should be derived as follows, using the most sensitive end-point in the most relevant study (WHO 2006):
TDI =(NOAEL or LOAEL) / UF
where:
- NOAEL = no-observed-adverse-effect level
- LOAEL = lowest-observed-adverse-effect level
- UF = uncertainty factor
References
- WHO (2006) Guidelines for Drinking-water Quality, First Addendum to Third Edition, Volume 1, Recommendations.
- WHO (2004) IPCS Risk assessment terminology: Internationally harmonized terms in relation to chemicals, Geneva.
Links
- WHO — The Health and Environment Lexicon
- [WHO Guidelines for Drinking-water Quality]
